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Postdoc & PhD-Kinesin Research-Ben-Gurion University of the Negev, Israel (Beer-Sheva)

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Location: Beer-Sheva, Israel

Deadline: 21/08/2016

Description

Ben Gurion University was established in 1969 as the University of the Negev with the aim of promoting the development of the Negev desert that comprises more than sixty percent of Israel. The University was later renamed after Israel’s founder and first prime minister David Ben-Gurion, who believed that the future of the country lay in this region. After Ben-Gurion’s death in 1973, the University was renamed Ben-Gurion University of the Negev.

Today, Ben-Gurion University is a center for teaching and research with about 20,000 students. Some of its research institutes include the National Institute for Biotechnology in the Negev, the Ilse Katz Institute for Nanoscale Science and Technology, the Jacob Blaustein Institutes for Desert Research with the Albert Katz International School for Desert Studies, and the Ben-Gurion Research Institute for the Study of Israel and Zionism.

Postdoctoral and Ph.D. positions are available to investigate the mechanism and regulation of directionality switch of the mitotic kinesin-5 motor proteins. Chromosome segregation during mitosis is mediated by the bipolar spindle, a highly dynamic microtubule (MT)-based structure. One of the major factors that govern spindle dynamics is the function of kinesin-5 motor proteins that utilize ATP to move along the MT tracks. Although kinesin-5 motors were believed to be plus-end directed, we had recently reported that on the single molecule level, the S. cerevisiae kinesin-5 homologs Cin8 and Kip1 move processively towards the minus-end of MTs. Moreover, they switch directionality under different experimental conditions (Fridman et al., 2013; Gerson-Gurwitz et al., 2011; Shapira and Gheber, 2016). The successful postdoctoral and Ph.D. candidates will join interdisciplinary research aimed at elucidating the mechanism and regulation of the unique directionality switch of kinesin-5 motors.

Qualifications:

  • Proven experience in molecular cloning/microscopy/protein purification
  • Publication record for postdoctoral fellows: at least two publications
  • Passion for science and strong work ethic
  • Strong written, oral and interpersonal communication skills
  • Able to work independently, to develop collaborations and to build a positive environment, taking initiatives for the benefit of the whole laboratory

How to apply

Interested individuals please send a statement of interest, a CV, and name and contact information of 2 references to lgheber@bgu.ac.il

For more information, visit //in.bgu.ac.il/en/natural_science/chem/lgheber/Pages/default.aspx

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