Postdoc-Pathogen Signalling Research-The Francis Crick Institute, UK (London)
Location: London, United Kingdom
The Francis Crick Institute (formerly the UK Centre for Medical Research and Innovation) is a biomedical research centre currently under construction in London, United Kingdom that opened in 2016. The Institute is a partnership between Cancer Research UK, Imperial College London, King’s College London (KCL), the Medical Research Council, University College London (UCL) and the Wellcome Trust. The Institute is planned to have 1,500 staff, including 1,250 scientists, and an annual budget of over £100 million,making it the biggest centre for biomedical research and innovation in Europe.
Parasites are subversive; they modify their environment to their own needs. Toxoplasma gondii is a member of a large group of intracellular parasites (the Apicomplexa to which also the malaria parasite Plasmodium falciparum belongs), that infect and extensively modify the host cell. Toxoplasma is one of the most successful parasites known, infecting up to 30% of the human population. While in most cases the parasite remains in a dormant form, controlled by the human immune system, it can be fatal and cause severe medical problems. If unchecked by the immune system, Toxoplasma parasites undergo successive rounds of host-cell invasion, multiplication and exit from the cell. This exponential growth is a major determinant of pathogenicity.
We have previously identified a calcium-dependent kinase that is central to rapid exit from the infected host-cell and identified a large number of proteins that are directly or indirectly affected by inactivation of this kinase (Treeck et al., 2014). Understanding the functional role of these proteins in the process of rapid host-cell exit is the major aim of this project. We use a large array of methods for our research ranging from imaging to quantitative mass-spectrometry and offer a diverse and stimulating research environment. For a full overview of projects in the lab visit www.treecklab.org.
We are seeking outstanding, highly motivated team players with a strong background in immunology, structural biology, signalling research or cell biology. Experience with RNAseq data analysis is desirable.
PLEASE NOTE: ALL OFFERS OF EMPLOYMENT ARE SUBJECT TO SUCCESSFUL SECURITY SCREENING AND CONTINUOUS ELIGIBILITY TO WORK IN THE UNITED KINGDOM.
How to apply
If you are interested in applying for this role, please apply via our website //www.jobs.crick.ac.uk.