Postdoc-Immunosurveillance-Francis Crick Institute, UK (London)


Location: London, United Kingdom
Deadline: 23/07/2016


This is a full-time fixed term position for 4 years on Crick Terms & Conditions of Employment, Salary is competitive plus benefits, subject to skills and experience. The Francis Crick Institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.
The institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role training scientists and developing ideas for public good. On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. From the second half of 2016, the Crick will move to a single new, purpose-built research centre in St. Pancras which will house some 1,500 staff.
We seek a talented, highly motivated post-doctoral scientist to contribute to understanding how lymphocytes function within epithelial tissues to join Adrian Hayday’s laboratory at the Francis Crick Institute.


Dr Hayday’s laboratory focuses on how defined molecules expressed by epithelial cells regulate the composition and activity of gamma delta T cells at mucosal surfaces in animals and in humans. They have developed the ‘Lymphoid Stress Surveillance’ hypothesis whereby tissue-associated T cells recognise and respond rapidly to perturbations to epithelia cells. This under-studied biology is distinguishable from conventional T cell responsiveness by its rapidity and by its capacity to monitor perturbations induced by non-microbial challenges, such as carcinogens or oxidative stress.
Details of research projects currently being undertaken can be seen at:
// Research techniques used in the laboratory include functional genomics, flow cytometry, and classical techniques of biochemistry and molecular biology.

Person Specification

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:


•An outstanding scholastic track-record
•A PhD qualification in immunology or a closely related discipline
•Considerable experience in flow cytometry and other cellular and molecular immunological methods
•Experience of working on gut and/or mucosal immunology
•Experience of working on model systems
•Experience of using infections and other perturbations to modulate the immune system in vivo
•Experience of inflammation-cytokine biology
•A strong publication record from their PhD training
In addition to the above, the successful candidate will be highly motivated, experimentally adept, and articulate in the dissemination of their results. He/she will take an active interest in their colleagues’ research and provide constructive feedback.
Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

How to apply

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