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Postdoc-Immune Involvement in Therapeutic Models of Cancer-Technical University of Denmark, Denmark (Lyngby)

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Location: Lyngby, Denmark
Deadline: 09/08/2016

Description

The Technical University of Denmark, often simply referred to as DTU, is a university in Kongens Lyngby, just north of Copenhagen, Denmark. It was founded in 1829 at the initiative of Hans Christian Ørsted as Denmark’s first polytechnic, and is today ranked among Europe’s leading engineering institutions.

A postdoctoral position is available in the ‘T cell recognition and Cancer’ group headed by Associate Professor Sine Reker Hadrup at the Section of Immunology and Vaccinology, at the Technical University of Denmark, Veterinary Institute, Frederiksberg.The ‘T cell recognition and Cancer’ group is currently consisting of 15 people, including Postdocs, PhD students, Technicians and undergraduate students. The overall aim of the research group is to gain novel insight to T cell recognition of cancer and autoimmune diseases, through use and development of novel technologies.

Responsibilities and tasks

The postdoc will be responsible for a project focusing on the immune involvement in radiotherapy and the effect of combining radiotherapy and immunotherapy. This has proven a promising strategy to boost the immune infiltration and induce tumor cell killing. In mouse models, we will assess the immunological factors contributing to this effect. In addition, through the use of MHC multimers we will assess the specific recognition of antigens induced during such therapy, with specific focus on the impact of neoantigens. We will specifically assess the CD8 T cell recognition in these models through application of a novel MHC multimer-based technology, developed in the research group.The project is closely related to other ongoing project in the group, and collaboration and shared responsibility across projects in the research team is expected.The task includes multicolor flow cytometry of diverse immune cell subsets, selection of targets for immune recognition based on gene expression or deep sequencing analysis. T cell recognition is assessed through use of in house produced peptide-MHC multimers.

Qualifications

Candidates should have a PhD degree or equivalent. It is important that the applicant has knowledge in the field of T cell immunology, cancer biology, and tumor immunology. Additionally experience with use of MHC-multimers for T cell detection is preferred. Experience with Flow Cytometry is required.
Experience with the following is advantageous: QPCR, Deep sequencing, Cell culturing of mouse lymphocytes and tumor cells, Functional T cell assays, Personal qualifications, Dedication and flexibility, Team player, yet with an independent project focus, Working in an international environment, Take responsibilities beyond your individual project.
We offer: High-level research environment and expertise in the relevant field, Large research network, Access to relevant clinical material or disease models, A social research group and department, International environment, Relevant instruments and lab equipment, We offer an interesting and challenging job in an international environment focusing on education, research, public-sector consultancy and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.

Salary and terms of employment

The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union. The period of employment is 2 years (with the possibility of an extension).

Start date: October 1st 2016 or asap thereafter.
The laboratory is located in Frederiksberg, Copenhagen at the DTU Vet Campus with expected move to Lyngby Campus beginning of 2017.

Further information

Further information may be obtained from Associate Professor Sine Reker Hadrup, sirha@vet.dtu.dk or Head of Section Jørgen Schøller, jorsch@vet.dtu.dk.You can read more about the research group at our homepage (//www.vet.dtu.dk/Forskning/Immunologi-og-Vaccinologi/Forskning/Sine-Reker-Hadrup)

How to apply

Please submit your online application no later than 9 August 2016. Apply online at www.career.dtu.dk. Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply online,” fill in the online application form, and attach all your materials in English in one PDF file. The file must include:
Application (cover letter)
CV
Diploma (an official translation into English)
List of publications

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