Postdoc-Biochemistry/Protein Chemistry-Institute of Organic Chemistry and Biochemistry AS CR, vvi, Czech Republic (Praha)


Location: Flemingovo náměstí 542/2 166 10 Praha 6  Czech Republic

Deadline: 24/07/2016


We are seeking a highly motivated individual who is willing to accept the challenge of cutting edge research at the interface biochemistry/protein chemistry of insulin and IGF analogues.

Job Description

This program could provide understanding of the structural basis for the different cellular responses – metabolic and mitogenic – generated by insulin, IGF-I and IGF-II, respectively. This effort could also result in IR-B or IR-A selective insulins or IGF-1R selective IGFs or IGF-1R antagonists. Such molecules could find applications in treatment of diabetes or cancer.

Successful applicant for this postdoc position will be an outstanding self-driven person who will primarily explore the total chemical synthesis of insulin and IGF-I analogues and receptor-binding assays of the analogues altogether with a contribution towards physicochemical characterization of analogues. Experience with a recombinant production of proteins would be appreciated.

Located in the stunning city of Prague, our research facilities comprise a state-of-the-art instrumentation portfolio (//


Applicant must have PhD in biochemistry, chemistry or a closely related discipline. The candidates must be a first author on at least 2-3 publications. This position requires prior experience in biochemistry and protein/peptide chemistry techniques. Excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.

Position is for 15 months starting from August 1st 2016 with possible extension.

How to apply

Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to:

Contacts: Jiří Jiráček, PhD

Institute of Organic Chemistry and Biochemistry of the ASCR

Flemingovo n. 542/2,

166 10 Prague 6,

Czech Republic



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